Can organ on a chip platforms be used to culture and maintain functional hematopoietic stem cells and progenitor cells (HSPC)? This is a recent paper from Sharipol et al. from the University of Rochester, culturing important components of murine bone marrow microenvironment (BMME) in an organ on a chip....
Intestinal organoids have found application in modeling intestinal function and infection, but is it feasible to replicate gastrointestinal motility and microbiome stability with organoids? One of the limitations is to access their lumens and modify their contents. A challenge that Ginga et al. at the Georgia Institute of Technology...
An interesting paper from Kim and Rhee groups at Korea Basic Science Institute and Incheon National University co-culturing glioblastoma with microglial cells in a tumor on a chip. They investigated therapeutic effects of microRNAs on tumor progression in brain cancer. The authors loaded microRNA-124 into extracellular vesicles, as a potential therapeutic...
A recent paper from Cromwell et al. in Burow lab in Tulane university modeling multifunctional profile of breast cancer tumoroids to investigate the effect of relative anti-cancer drugs on tumoroid phenotype and cell metabolism function. Authors initially cultured cells isolated from patients in conventional cell culture dishes and later...
A nice collaborative paper from Stelzle, Gebhardt and Mayr labs in U. of Tübingen, Leipzig University and TU Graz monitoring oxygen and liver tissue metabolism in a well-plate format organ on a chip system. They used oxygen patches and optical fibers to monitor oxygen levels in the medium around...
A recent paper from Jang et al. from Kuh’s lab at the Catholic University of Korea co-culturing pancreatic cancer cells with fibroblasts and macrophages to create a 3D tumor on a chip model. The paper evaluates the culture of the cancer cells with and without the stromal cells and...
A recent paper from Le Pioufle lab at CNRS France modelling the microstructure of the hepatic cord within the liver by confining hepatocytes in tiny hepatic-cord like chambers in a liver on a chip system. These chambers are in contact with another channel containing various media through tiny slits...
A Very beautiful paper from Park (Sungkyunkwan U.) and Sung (Hongik U.) labs integrating intestine on a chip and kidney on a chip in one model to study the effect of two antibiotics on E. coli infection and their consequences on kidney injury. This multi-organ on a chip model...
A recent paper by Kim and Chung groups from the Catholic University of Korea culturing vascularized organoids in a kidney on a chip platform and studying the role of shear stress on the formation and nephrotoxicity of the organoids. The authors cultured organoids in a static culture and injected...
A beautiful paper from Ertl group at Vienna University of Technology co-culturing synovial and chondral organoids in a joint on a chip to study Rheumatoid Arthritis. They used a compartmentalized chip to establish a cross-talk between Matrigel embedded synovial organoids and chondral organoids embedded in a fibrin gel. It...
