This is a common question: what extracellular matrix (ECM) should I use? Specifically, the choice of matrix is very important to mimic the tumor–stromal cells interaction during cancer intravasation. This paper by Agrawal et al. from the Moeendarbary lab at University College London uses a tumor on a chip...
Can organ on a chip platforms be used to culture and maintain functional hematopoietic stem cells and progenitor cells (HSPC)? This is a recent paper from Sharipol et al. from the University of Rochester, culturing important components of murine bone marrow microenvironment (BMME) in an organ on a chip....
How can you use a tumor on a chip platform to study the effect of immune checkpoint inhibitors (ICIs) on lymphocytes and cancer cells? This is a recent paper from Sieviläinen et al. at the university of Helsinki that uses an organ on a chip, lymphocytes and head and...
Can organ on a chip systems be adopted for ADME and quantitative drug metabolism studies? This is a recent paper from Docci et al. from the University of Basel that use the liver on a chip from Cn-bio to estimate pharmacokinetic parameters and drug metabolism of cultured primary hepatocytes...
How can organ-on-a-chip improve cardiac microtissue maturation and function? Recapitulating complex myocardial tissue has always been challenging due to its complex biochemical and biophysical characteristics. This is a recent paper from Moreira et al. at the polytechnic university of Milan where the authors study how the perfusion of culture...
An interesting paper from Kim and Rhee groups at Korea Basic Science Institute and Incheon National University co-culturing glioblastoma with microglial cells in a tumor on a chip. They investigated therapeutic effects of microRNAs on tumor progression in brain cancer. The authors loaded microRNA-124 into extracellular vesicles, as a potential therapeutic...
A recent paper from Cromwell et al. in Burow lab in Tulane university modeling multifunctional profile of breast cancer tumoroids to investigate the effect of relative anti-cancer drugs on tumoroid phenotype and cell metabolism function. Authors initially cultured cells isolated from patients in conventional cell culture dishes and later...
A nice collaborative paper from Stelzle, Gebhardt and Mayr labs in U. of Tübingen, Leipzig University and TU Graz monitoring oxygen and liver tissue metabolism in a well-plate format organ on a chip system. They used oxygen patches and optical fibers to monitor oxygen levels in the medium around...
A beautiful paper from Ertl group at Vienna University of Technology co-culturing synovial and chondral organoids in a joint on a chip to study Rheumatoid Arthritis. They used a compartmentalized chip to establish a cross-talk between Matrigel embedded synovial organoids and chondral organoids embedded in a fibrin gel. It...
A recent paper from Jain lab at Texas A&M University that studies the extravasation of platelets into the ovarian tumor microenvironment in a microfluidic chip. The presented tumor-on-a-chip reveals the dynamics of cancer cell-platelet interaction towards more metastatic behavior in cancer cells. Results The authors published a similar technology...
