This is a common question: what extracellular matrix (ECM) should I use? Specifically, the choice of matrix is very important to mimic the tumor–stromal cells interaction during cancer intravasation. This paper by Agrawal et al. from the Moeendarbary lab at University College London uses a tumor on a chip...
An interesting paper from Kim and Rhee groups at Korea Basic Science Institute and Incheon National University co-culturing glioblastoma with microglial cells in a tumor on a chip. They investigated therapeutic effects of microRNAs on tumor progression in brain cancer. The authors loaded microRNA-124 into extracellular vesicles, as a potential therapeutic...
A recent paper from Jang et al. from Kuh’s lab at the Catholic University of Korea co-culturing pancreatic cancer cells with fibroblasts and macrophages to create a 3D tumor on a chip model. The paper evaluates the culture of the cancer cells with and without the stromal cells and...
A beautiful paper from Hasse lab at EMBL Barcelona modelling fibrosis in the lung and heart to study the implications of fibrosis on microvasculature. They used a macro-scale side-by-side channel chip, previously developed in the lab of Roger Kamm. The authors developed this vasculature on a chip to assess...
