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Tag: Cells suspended in hydrogel

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  • 21
    Dec

    Matrix composition modulates vasculature formation and intravasation in tumor chip

    This is a common question: what extracellular matrix (ECM) should I use? Specifically, the choice of matrix is very important to mimic the tumor–stromal cells interaction during cancer intravasation. This paper by Agrawal et al. from the Moeendarbary lab at University College London uses a tumor on a chip...

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  • 08
    Nov

    Bone Marrow Microenvironment on a chip for culture of functional hematopoietic stem cells

    Can organ on a chip platforms be used to culture and maintain functional hematopoietic stem cells and progenitor cells (HSPC)? This is a recent paper from Sharipol et al. from the University of Rochester, culturing important components of murine bone marrow microenvironment (BMME) in an organ on a chip....

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  • 23
    Aug

    Automated perfused heart-on-a-chip mimicking cardiac micro-tissue maturation and function

    How can organ-on-a-chip improve cardiac microtissue maturation and function? Recapitulating complex myocardial tissue has always been challenging due to its complex biochemical and biophysical characteristics. This is a recent paper from Moreira et al. at the polytechnic university of Milan where the authors study how the perfusion of culture...

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  • 09
    Jun

    Multi-organ model of thyroid-liver axis to study endocrine disruption

    A beautiful thyroid-liver axis model of endocrine disruption studying the thyroid-stimulating hormone (TSH)-dependent triiodothyronine (T3) secretion in a dynamic multi-organ chip. This is a joint publication between Bayer and TissUse with a beautiful characterization of the 3D liver and thyroid models. ResultsThe authors used different concentrations of TSH to...

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  • 24
    May

    MicroRNA loaded extracellular vesicles affect tumor microenvironment in Tumor on a chip

    An interesting paper from Kim and Rhee groups at Korea Basic Science Institute and Incheon National University co-culturing glioblastoma with microglial cells in a tumor on a chip. They investigated therapeutic effects of microRNAs on tumor progression in brain cancer. The authors loaded microRNA-124 into extracellular vesicles, as a potential therapeutic...

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  • 12
    Jan

    3D pancreatic tumor spheroids co-cultured with stromal cells in an organ on a chip

    A recent paper from Jang et al. from Kuh’s lab at the Catholic University of Korea co-culturing pancreatic cancer cells with fibroblasts and macrophages to create a 3D tumor on a chip model. The paper evaluates the culture of the cancer cells with and without the stromal cells and...

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  • 09
    Nov

    Flow and vascularization of kidney organoids on a chip

    A recent paper by Kim and Chung groups from the Catholic University of Korea culturing vascularized organoids in a kidney on a chip platform and studying the role of shear stress on the formation and nephrotoxicity of the organoids. The authors cultured organoids in a static culture and injected...

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  • 03
    Nov

    Chondro-synovial cross-talk in Rheumatoid Arthritis modelling organ on a chip

    A beautiful paper from Ertl group at Vienna University of Technology co-culturing synovial and chondral organoids in a joint on a chip to study Rheumatoid Arthritis. They used a compartmentalized chip to establish a cross-talk between Matrigel embedded synovial organoids and chondral organoids embedded in a fibrin gel. It...

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  • 12
    Oct

    Fibrosis and Microvasculature on a chip

    A beautiful paper from Hasse lab at EMBL Barcelona modelling fibrosis in the lung and heart to study the implications of fibrosis on microvasculature. They used a macro-scale side-by-side channel chip, previously developed in the lab of Roger Kamm. The authors developed this vasculature on a chip to assess...

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  • 21
    Jun

    Immune cell infiltration to synovium in joint on a chip

    A beautiful paper from Moretti/Lopa group integrating cartilage-on-a-chip and synovium-on-a-chip to present a unique joint-on-a-chip model. This model recapitulated monocyte extravasation into the synovium of patients with osteoarthritis. The system was composed of synovial compartment included a perfusable endothelialized channel for monocyte injection, a chondral compartments, and a channel...

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