A beautiful paper from Hasse lab at EMBL Barcelona modelling fibrosis in the lung and heart to study the implications of fibrosis on microvasculature. They used a macro-scale side-by-side channel chip, previously developed in the lab of Roger Kamm. The authors developed this vasculature on a chip to assess...
This recently published paper from Musah lab at Duke university is a beautiful validation of using kidney on a chip to model glomerular filtration. This tissue chip was lined by epithelial and endothelial cells to mimic the blood filtration barrier and selective molecular filtration function of the kidney. Using...
Choosing an organ on a chip system can be confusing, but few resources can help make the process easier. One excellent example is the The North American 3Rs Collaborative tech hub which sorts commercial systems by organ types. We highly recommend you visit and get to know available organ...
A recently published paper from Hesperos Inc./Hickman lab at University of Central Florida co-culturing human hepatocytes and adipocytes representing white adipose tissue. In this multi-organ on a chip different serum-free media formulations were used to represent different human metabolic states. Results The system made the crosstalk between liver-on-a-chip and...
AZAR Innovations helps technology providers connect to the right applications in organ on a chip field. We would love to know more about the potentials of your technology and assist you to find the niches that your technology excels at. Consulting at AZAR Innovations Want to discuss how we...
Adding perfusion to organ on a chip devices adds a layer of complexity, so we need to see clear added values to introduce flow in an in vitro system.Here are a few examples of why perfusion could be useful in organ on a chip.Any comments or questions? Please feel...
A beautiful paper from Moretti/Lopa group integrating cartilage-on-a-chip and synovium-on-a-chip to present a unique joint-on-a-chip model. This model recapitulated monocyte extravasation into the synovium of patients with osteoarthritis. The system was composed of synovial compartment included a perfusable endothelialized channel for monocyte injection, a chondral compartments, and a channel...
Shear stress on cells in an organ on a chip is due to the movement of culture medium on top of the cells. It is a force per unit area parallel to the cell layer. Flow in a rectangular microchannel increases with flow rate but increases even faster with...
Not many systems can mimic the Aerobic-Anaerobic interface of the large intestine. A not-so-old paper from the Wyss institute creates a hypoxic gradient across their intestine-on-a-chip. In this study, the chip comprised epithelial cells on top of a porous membrane and bacteria cultured above the epithelium under a hypoxia...
It is easy to confuse diffusion with flow. In simple terms: Diffusion: due to a concentration gradient of a solute, molecules move in the medium from a higher to lower concentration. Flow: Due to a pressure gradient in the medium, the medium itself moves from a higher to a...
