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Most devastating symptom for osteoarthritis (OA) patients is pain. But frequently this is inadequately managed which has profound negative impact on both physical and mental health. Problem is that preclinical test are still performed in rodents, known to be essentially different from humans. Moreover, pain studies in animal models use behavior as a proxy for pain but lack essential quantification of sensory neuron outgrowth and activity. Better human models to test drugs to relief pain in OA are essential to advance development of safe and effective therapies.

In this 8-month project, we together with our collaborators at Leiden University Medical Center will develop a Proof-of-Concept that mimics essential aspects of human OA pathophysiology including pain-sensing neurons. Read more!

Interested in knowing more about our organ on a chip support? Contact us!