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Tag: LC-MS

  • 14

    Automatic pharmacokinetic drug exposure in tumor spheroid on a chip

    Normally, you would have to wash your cells many times before and after drug exposure, especially if you want to create pharmacokinetic (PK) exposure profile in your system. Here is the thing: what if you had an automatic perfusion system that can do this automatically? This is possible with...

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  • 19

    Liver-on-a-chip and mathematical modeling for drug metabolism studies

    Can organ on a chip systems be adopted for ADME and quantitative drug metabolism studies? This is a recent paper from Docci et al. from the University of Basel that use the liver on a chip from Cn-bio to estimate pharmacokinetic parameters and drug metabolism of cultured primary hepatocytes...

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  • 09

    Multi-organ model of thyroid-liver axis to study endocrine disruption

    A beautiful thyroid-liver axis model of endocrine disruption studying the thyroid-stimulating hormone (TSH)-dependent triiodothyronine (T3) secretion in a dynamic multi-organ chip. This is a joint publication between Bayer and TissUse with a beautiful characterization of the 3D liver and thyroid models. ResultsThe authors used different concentrations of TSH to...

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  • 12

    Intestine-liver interaction affects hepatocyte function in multi-organ chip

    Everyone can pipette conditioned media of an intestinal cell culture into a hepatocyte model to study intestine–liver interaction. But what if you could use the same cell models and not only to make this process automatic (save money), but also to control the cross-talk (more flexibility)? Enjoy this paper...

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