Intestinal organoids have found application in modeling intestinal function and infection, but is it feasible to replicate gastrointestinal motility and microbiome stability with organoids? One of the limitations is to access their lumens and modify their contents. A challenge that Ginga et al. at the Georgia Institute of Technology...
A beautiful paper from Jianhua Qin’s lab from the Chinese Academy of Sciences modelling Liver–pancreatic Islet Axis. They used a multi-organoid organ on a chip system to study glucose regulation in physiological and pathological conditions. After culturing the hiPSCs in “micro-wells” and creating embryonic bodies, the authors differentiated them...
A recent paper from Cromwell et al. in Burow lab in Tulane university modeling multifunctional profile of breast cancer tumoroids to investigate the effect of relative anti-cancer drugs on tumoroid phenotype and cell metabolism function. Authors initially cultured cells isolated from patients in conventional cell culture dishes and later...
A recent paper by Kim and Chung groups from the Catholic University of Korea culturing vascularized organoids in a kidney on a chip platform and studying the role of shear stress on the formation and nephrotoxicity of the organoids. The authors cultured organoids in a static culture and injected...
A beautiful paper from Ertl group at Vienna University of Technology co-culturing synovial and chondral organoids in a joint on a chip to study Rheumatoid Arthritis. They used a compartmentalized chip to establish a cross-talk between Matrigel embedded synovial organoids and chondral organoids embedded in a fibrin gel. It...
A recent paper from Jain lab at Texas A&M University that studies the extravasation of platelets into the ovarian tumor microenvironment in a microfluidic chip. The presented tumor-on-a-chip reveals the dynamics of cancer cell-platelet interaction towards more metastatic behavior in cancer cells. Results The authors published a similar technology...
A beautiful paper from Hasse lab at EMBL Barcelona modelling fibrosis in the lung and heart to study the implications of fibrosis on microvasculature. They used a macro-scale side-by-side channel chip, previously developed in the lab of Roger Kamm. The authors developed this vasculature on a chip to assess...
A recently published paper from Hesperos Inc./Hickman lab at University of Central Florida co-culturing human hepatocytes and adipocytes representing white adipose tissue. In this multi-organ on a chip different serum-free media formulations were used to represent different human metabolic states. Results The system made the crosstalk between liver-on-a-chip and...
A beautiful paper from Moretti/Lopa group integrating cartilage-on-a-chip and synovium-on-a-chip to present a unique joint-on-a-chip model. This model recapitulated monocyte extravasation into the synovium of patients with osteoarthritis. The system was composed of synovial compartment included a perfusable endothelialized channel for monocyte injection, a chondral compartments, and a channel...
