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Tag: ADME

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  • 19
    Oct

    Liver-on-a-chip and mathematical modeling for drug metabolism studies

    Can organ on a chip systems be adopted for ADME and quantitative drug metabolism studies? This is a recent paper from Docci et al. from the University of Basel that use the liver on a chip from Cn-bio to estimate pharmacokinetic parameters and drug metabolism of cultured primary hepatocytes...

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  • 12
    Apr

    Intestine-liver interaction affects hepatocyte function in multi-organ chip

    Everyone can pipette conditioned media of an intestinal cell culture into a hepatocyte model to study intestine–liver interaction. But what if you could use the same cell models and not only to make this process automatic (save money), but also to control the cross-talk (more flexibility)? Enjoy this paper...

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  • 27
    May

    10 key features Multi-organ-on-chips for drug disposition assessment

    10 key features Multi-organ-on-chips should have for drug disposition assessment as alternative to animal testing.These are the highlights of our recent paper written by Dr. Damiën van Berlo, Dr. Evita van de Steeg and Prof. Roos Masereeuw.Also check out the systematic biological and technical categorization of available multi-organ-on-chip models....

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