Description
Photo of the event:
For the second time in a row, University of Amsterdam and AZAR Innovations jointly organise an Organ on a chip MasterClass focusing on Intestine and intestine-microbiome models on chip. This with live virtual training by STEMCELL Technologies.
TARGET GROUP: Biomedical scientists from academia and industry from around the world who wish to get started or gain more experience with intestine and intestine-microbiome on chips.
Date: 26 June 2024 8:30 – 28 June 2024 12:30
Location: Science Park 904, Amsterdam, the Netherlands
GOAL: Help scientists adopt, develop or use organ on a chip assays more efficiently.
Watch this video to find out more about the contents of this MasterClass (00:00-09:00):
This MasterClass consists of:
1. On-demand e-learning
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- What is Organ on a chip?
- Why would you use organ on a chip?
- What components does an organ on a chip system have?
- What design types can you find?
- How do you choose the closest organ on a chip system to your application?
- Advantages and disadvantages of every design type.
- Go through a few examples.
2. Live virtual lab session: Maintaining and assessing high quality intestinal organoid cultures by STEMCELL Technologies
Trainer: Julie Watson, Scientific Support Scientist
Backup trainer: Shyam Jose, Scientific Support Specialist
In this interactive session, scientists from STEMCELL Technologies will explain how to set up and passage intestinal organoids. The session will combine lecture slides and pre-recorded laboratory demonstrations. We’ll overview the techniques involved, review typical morphologies, and demonstrate the organoid establishment and passaging protocols. You will be able to ask questions in real time about technical aspects of the workflow, and how organoids can be used to facilitate your research.
3. Interactive lectures
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- A custom-made summary of on-demand lectures.
- Examples GI tract chips
- How are chips made?
- How do you prepare chips for cell culture?
- How do you (co-)culture cells in chips?
- How do you connect chips to flow systems?
- How do you extract data from an intestine on a chip system?
- Explore different commercial GI tract microphysiological models
4. Hands-on lab training
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- Work with 4 different chip types
- Work with 5 different flow systems (pumps)
- Connect pumps to organ chips and other components
- Learn about different protocols
- Simulate cell seeding with microparticles
- Use microscopy to observe organ chips
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5. Commercial demos
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- Hands-on experience with selected commercial intestine & intestine-microbiome chips
- Ask questions directly from technology providers
- Discuss collaborations with companies
- Commercial demo table
- Get inspired for your design
Dynamic 42 develops immunocompetent, physiological organ-on-chip models and has a strong background in disease and infection modeling. The company offers contract research for preclinical drug evaluation, a variety of medical-grade, low drug adsorption biochips and hands-on training courses within their Dynamic42 Academy.
Mimetas is a global leader in 3D disease modeling using Organ-on-a-Chip technologies. With their screenable, physiologically relevant human disease models, MIMETAS establishes strong partnerships with and offers services to global pharmaceutical companies to develop innovative therapies to target untreatable diseases.
Watch this video to find out more about the technologies from Dynamic 42 (17:30-49:40) and Mimetas (49:40-77:45):
6. Design your intestine on a chip assay
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- Design your idea following the previous sessions
- Use our methodical canvasses to identify system requirements
- Use our design tools to design your own system
- Get inspired by our database of published articles
- Receive supervision from our trainers
- Present your design to experts and receive feedback
7. Expert views
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- Discover applications of organ on chips with experts
- Interact with the experts
- Get inspired for your own system design
“Rebuild the complexity: an organoids-derived, immune- and microbiome-competent gut model”
Dr. Jianbo Zhang
Department of Molecular Biology and Microbial Food Safety
Swammerdam Institute for Life Sciences
University of Amsterdam
Amsterdam, the Netherlands
Watch this video to find out more about Dr. Zhang’s work (09:00-16:30):
“Organoid and organ-on-chip models for the small intestine“
Dr. Sebo Withoff
Associate Professor
Immunogenetics Lab – Department of Genetics
University Medical Center Groningen
Groningen, The Netherlands
Trainers:
Dr. Hossein Eslami Amirabadi is a bioengineer with more than 10 years of experience developing organ on a chip systems for and with biologists. He is an instructor to biomedical scientists since 2015 in academia and industry. He has helped scientists to develop:
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- Intestinal transport on a chip
- Intestine-microbiome on chip
- Bone regeneration on chip
- Metastasis to vascularized bone chip
- Drug disposition gut-kidney-liver on chip
- Cartilage organoid growth on chip
- 3D breast tumor invasion on a chip
- Osteochondral unit on a chip
Emre Dilmen, MSc is a biologist with a passion for engineering solutions, with more than 5 years of experience working with organoids and developing organ on a chip systems with engineers. He has worked on:
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- Kidney organoids and tubuloids
- Intestinal transport on a chip
- Kidney tubuloids on a chip
Cannot attend this event? Take a look at other MasterClasses here, or fill in this form to know about upcoming Organ on a chip MasterClasses.
Any questions? Feel free to send us an email via [email protected].
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