10 key features Multi-organ-on-chips should have for drug disposition assessment as alternative to animal testing.These are the highlights of our recent paper written by Dr. Damiën van Berlo, Dr. Evita van de Steeg and Prof. Roos Masereeuw.Also check out the systematic biological and technical categorization of available multi-organ-on-chip models....
Reproducibility is one of the serious issues in organ on a chip. Creating clear and reproducible protocols from the start can help address this issue. – Make protocols together with life scientists– While doing this, think whether others can follow– Ask colleagues, especially with other backgrounds, to repeat the...
Pressure is a concept in organ on a chip that sounds simple but not trivial in practice. It is handy to know:– Culture medium always flows from higher to lower pressure– Pressure higher than environment can lead to leakage of medium (positive pressure)– Pressure lower than environment can lead...
A new paper from DRAPER, not a lot of manuscripts get accepted only after 2 months like this one! This organ on a chip platform may be less known, but definitely has features that catch eyes: Positive points+ A higher throughput platform with 96 chips in one plate+ Double...
Organ on a chip end-users can contribute to organ on a chip development too! Technical scientists can get help from them since they– know all about cells and tissues,– know about the consumables and equipment used in biology,– can experience the “Ikea effect” once they contribute,– can learn design...
Do you have a technical problem in your #OrganOnAChip system? Why spending weeks and months trying to solve it? Why not getting help from an expert? Or do you want to change the #design of your chip or a part of your system? Or run computational models to understand the flow or concentration...
Cell culture media flow in organ-on-a-chip systems often in a “laminar” form, but what does laminar mean? It simply means a very smooth flow, all the layers of the fluid move along each other very smoothly. Imagine cars in a traffic moving next to each other on a highway....
This post is about “YIELD” in organ on a chip systems. Before you start collaborating, make sure you communicate well about the experiment yield. Try to discuss:– the yield of the system,– whether this yield changes when you do more experiments, and– whether it changes if somebody else does...
Many organ on a chip systems use pumps to perfuse the micro-tissues they model, or in engineering terms, they have “flow” in the system. But you pay a price here: adding perfusion makes the system more complex! So, you really need to think: Do I really need perfusion in...
